Part, Category. Description, 4-bit Shift Register. Company, ETC. Datasheet, Download datasheet. Quote. Find where to buy. Quote. # Store at. °C. 5-Formylcytosine (5-fC) (D5D4K) Rabbit mAb . as recommended in the antibody product datasheet) in 10 ml primary antibody. Datasheet PDF Download – 4-Bit Shift Register, data sheet.

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Have trouble resetting your password? While 5-fC and 5-caC appear datasbeet be short-lived intermediate species, there is mounting evidence showing that 5-hmC is a distinct epigenetic mark with various unique 774178 10, Many cells and tissues contain very low endogenous levels of 5-fC that may fall below the detection limits of this antibody.

Please refer to this page. Since then this modification has been discovered in many tissues, with the highest levels found in the brain 9. Therefore webshop accounts that datashee only used to view prices have been deleted.

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Login No need to login to view prices! You will receive an e-mail from us containing your new password in the coming minutes. Methylation of DNA at cytosine residues is a heritable, epigenetic modification that is critical for proper regulation of gene expression, genomic imprinting, and dayasheet development 1,2.

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You will receive an e-mail containing a link to start the recovery procedure within minutes. Is your country not in this list? This product is intended for research purposes only. Additionally, TET proteins can further oxidize 5-hmC to form 5-formylcytosine 5-fC and 5-carboxylcytosine 5-caCboth of which are excised by thymine-DNA glycosylase TDGeffectively linking cytosine oxidation to the base excision repair pathway and supporting active cytosine demethylation 6,7.

The same sequence of a base datasheeg DNA fragment was generated by PCR using exclusively unmodified cytosine, 5-methylcytosine 5-mC5-hydroxymethylcytosine 5-hmC5-carboxylcytosine 5-caCor 5-formylcytosine 5-fC.

As shown in the graph, the antibody only binds to the oligo containing 5-fC. Application References Have you published research involving the use of our products?

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The current items in your cart are: The modified base itself is stable in vivo and interacts with various readers including MeCP2 11, We are committed to providing you with a productive and privacy-friendly website.

Our website shows product prices without login! Lower amounts of 5-hmC have been reported in various cancers including myeloid leukemia and melanoma 13, The global level of 5-hmC increases during brain development, and 5-hmC is enriched at promoter regions and poised enhancers.

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By dwtasheet on this website, you agree to the placement of these cookies. Contact us and we will help you. Please change your password to something memorable and secure upon logging in. Background Methylation of DNA at cytosine residues is a heritable, epigenetic modification that is critical for proper regulation of gene expression, genomic imprinting, and mammalian development 1,2.

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The product is not intended to be used for therapeutic or diagnostic purposes in humans or animals. The antibody was titrated against a single-stranded DNA oligo containing either unmodified cytosine or differentially modified cytosine 5-mC, 5-hmC, 5-caC, 5-fC.

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Please create a new account with your shipping and billing details if you would like to be able to order or view your discount. The supporting documents available for this product can be downloaded below. If so we’d love to hear about it. Product has been added to your cart. Datasheet Datasheet CST TET protein-mediated cytosine hydroxymethylation was initially demonstrated in mouse brain and embryonic stem cells 5, 8.

Furthermore, there is an inverse correlation between levels of 5-hmC and histone H3K9 and H3K27 trimethylation, suggesting a role for 5-hmC in gene activation Find your product Go. Like most websites, we make use of cookies to track your preferences.

The upper panel shows the antibody only binding to the DNA fragment containing 5-fC, while the lower panel shows the membrane stained with methylene blue. Login Create new account.

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