Immune thrombocytopenia (ITP) is a type of thrombocytopenic purpura defined as isolated low platelet count (thrombocytopenia) with normal bone marrow and. Amaç: İdiopatik trombositopenik purpura (ITP); trombositopenî, trombosit ömründe kısalma, plazmada anti-trombosit antikorların varlığı ve kemik iliğinde. Immune thrombocytopenic purpura (ITP) is a bleeding disorder in which the immune system destroys platelets, which are necessary for normal.
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Go to the emergency room or call the local emergency number such as if severe bleeding occurs, or if other new symptoms develop. This is because the underlying autoimmune mechanism that is destroying the patient’s platelets will also destroy donor platelets, and so platelet purpira are not considered a long-term treatment option. ITP is an autoimmune disease with antibodies detectable against several platelet surface antigens.
Intravenous immunoglobulin IVIg may be infused in some cases in order to decrease the rate at which macrophages consume antibody -tagged platelets. The clinical presentation may be acute with severe bleeding, or insidious with slow development with mild or no symptoms. Petechia, purpura, and easy bruising are expected in ITP.
Diseases of platelet number: National Heart, Lung, and Blood Institute — www. Retrieved October 16, The antibodies attach to the platelets. Bleeding time is usually prolonged in ITP patients. ABC of clinical haematology. Current guidelines recommend treatment only in cases of significant bleeding. In children, the disease sometimes idiopafik a viral infection. Idiopathic purpra purpura ITP is the condition of having a low platelet count thrombocytopenia of no known cause idiopathic.
Views Read Edit View history. A report of 66 cases. Hematoma, idiopathic thrombocytopenic purpura, petechiae, platelets. Platelets which have been bound by antibodies are taken up by macrophages in the spleen which have Fc receptorsand so removal of the spleen reduces platelet destruction. The dose and mode of administration is determined by platelet count and whether there is active trimbosit Platelet transfusions may be used in severe bleeding together with a very low count.
We present a case report on ITP with clinical presentation, diagnosis and teombosit. The mechanism of action of anti-D is not fully understood. British Journal of Haematology.
After several weeks of prednisone therapy, the dose is gradually reduced. There is no specific treatment for ITP. Author information Copyright and License information Disclaimer. Abstract Idiopathic thrombocytopenic purpura ITP is defined as a hematologic disorder, characterized by isolated thrombocytopenia without a clinically apparent cause. Retrieved from ” https: Platelet transfusions may be performed in newborns, depending on the degree of thrombocytopenia.
Idiopathic thrombocytopenic purpura
Immune thrombocytopenia  ITP is a type of thrombocytopenic purpura defined as isolated low platelet count thrombocytopenia with normal bone marrow and the absence of other causes of thrombocytopenia. Our case was abrupt and acute in onset. Despite the destruction of platelets by splenic macrophages, the spleen is normally not enlarged.
Medicine called danazol Danocrine taken by mouth Infusions of high-dose gamma globulin an immune factor Drugs that suppress the immune system Anti-RhD therapy for people with certain blood types Drugs that stimulate the bone marrow to make more platelets People with ITP should not take aspirin, ibuprofen, or warfarin, because these drugs interfere with platelet function or blood clotting, and bleeding may occur.
Intraoral examination revealed bleeding from gingiva in lower anterior region, which was inflamed, reddish, tender on palpation, soft in consistency [ Figure 3 ].
Immune thrombocytopenic purpura
Hence one may be considered thrombocytopenic below that range, although the threshold for a diagnosis of ITP is not hrombosit to any specific number. Past medical history revealed that patient was known case of epilepsy since 7 years of age and was on tablet eptoin, tablet carbamazepine for past 12 years.
Then, secondary causes 5—10 percent of suspected ITP cases should be excluded. Petechial spots on dorsum of tongue, petechial spot on left side hard palate and left maxillary tuberosity region. Chronic immune thrombocytopenia persists longer than six months with a specific cause being unknown. Freckles lentigo melasma nevus melanoma. An ITP patient with an extremely low count is vulnerable to internal bleeding caused by blunt abdominal traumaas might be experienced in a motor vehicle crash.
The acute form often follows an infection and has a spontaneous resolution within two months. Management of adult idiopathic thrombocytopenic purpura. In adults, particularly those living in areas with a high prevalence of Helicobacter pylori which normally inhabits the stomach wall and has been associated with peptic ulcersidentification and treatment of this infection has been shown to improve platelet counts in a third of patients.
Secondary causes could be leukemia, medications e. Patients with mild, asymptomatic thrombocytopenia, discovered incidentally on a routine blood count, should not be treated. ITP is a disorder that affects the overall number of blood platelets rather than their function. Bone pkrpura examination may be performed on patients over the age of 60 and those who do not respond to treatment, or when the diagnosis is in doubt.
Platelet Disorders Read more. Eltrombopag for the treatment of chronic idiopathic thrombocytopenic purpura. Long-term responses seen with rituximab in patients with ITP.
In a study conducted in Great Britainit was noted that ITP causes an approximately 60 percent higher rate of mortality compared to gender- and age-matched subjects without ITP.